产品名称
Casein Kinase Iγ1 Rabbit Polyclonal Antibody
别名
CSNK1G1; Casein kinase I isoform gamma-1; CKI-gamma 1
蛋白名称
Casein kinase I isoform gamma-1
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53944
Human Swissprot No.
Q9HCP0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9HCP0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=214897
Mouse Swissprot No.
Q8BTH8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BTH8
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64086
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q62761
免疫原
The antiserum was produced against synthesized peptide derived from human CKI-gamma1. AA range:1-50
特异性
Casein Kinase Iγ1 Polyclonal Antibody detects endogenous levels of Casein Kinase Iγ1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016],
组织表达
Brain,Muscle,Pooled,
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
