产品名称
Casein Kinase Iα Rabbit Polyclonal Antibody
别名
CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1
蛋白名称
Casein kinase I isoform alpha
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1452
Human Swissprot No.
P48729
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P48729/entry
Mouse Swissprot No.
Q8BK63
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BK63
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=113927
Rat Swissprot Link
http://www.uniprot.org/uniprot/P97633
免疫原
The antiserum was produced against synthesized peptide derived from human CKI-alpha. AA range:126-175
特异性
Casein Kinase Iα Polyclonal Antibody detects endogenous levels of Casein Kinase Iα protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Interacts with the Axin complex.,
组织表达
Brain,Epithelium,Liver,Lung,Placenta,Skin,
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Nucleus speckle . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, spindle . Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688). .
信号通路
WNT;WNT-T CELLHedgehog;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer. Interacts with the Axin complex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
