产品名称
Casein Kinase IIβ Rabbit Polyclonal Antibody
别名
CSNK2B; CK2N; G5A; Casein kinase II subunit beta; CK II beta; Phosvitin; Protein G5a
蛋白名称
Casein kinase II subunit beta
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1460
Human Swissprot No.
P67870
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P67870/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13001
Mouse Swissprot No.
P67871
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P67871
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81650
Rat Swissprot Link
http://www.uniprot.org/uniprot/P67874
免疫原
The antiserum was produced against synthesized peptide derived from human CKII-beta. AA range:166-215
特异性
Casein Kinase IIβ Polyclonal Antibody detects endogenous levels of Casein Kinase IIβ protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013],
细胞定位
nucleus,nucleoplasm,cytoplasm,cytosol,plasma membrane,protein kinase CK2 complex,PcG protein complex,extracellular exosome,
信号通路
WNT;WNT-T CELLAdherens_Junction;Adherens_Junction;
功能
function:Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.,PTM:N-glycosylated.,PTM:Phosphorylated by alpha subunit.,similarity:Belongs to the casein kinase 2 subunit beta family.,similarity:Contains 1 UPAR/Ly6 domain.,subunit:Forms oligomer.,subunit:Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
