BD-PT0643

Casein Kinase IIα Rabbit Polyclonal Antibody

CSNK2A1; CK2A1; Casein kinase II subunit alpha; CK II alpha

常规抗体

CSNK2A1

Casein kinase II subunit alpha

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1457

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1457

P68400

http://www.uniprot.org/uniprotkb/P68400/entry

12995

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12995

Q60737

http://www.uniprot.org/uniprot/Q60737

116549

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116549

P19139

http://www.uniprot.org/uniprot/P19139

The antiserum was produced against synthesized peptide derived from human Casein Kinase II alpha. AA range:221-270

Casein Kinase IIα Polyclonal Antibody detects endogenous levels of Casein Kinase IIα protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

45kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2014],

Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level).

Nucleus .

WNT;WNT-T CELLAdherens_Junction;Adherens_Junction;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Tetramer composed of an alpha chain, an alpha' and two beta chains. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with RNPS1.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.