BD-PT0640

CARP Rabbit Polyclonal Antibody

ANKRD1; C193; CARP; HA1A2; Ankyrin repeat domain-containing protein 1; Cardiac ankyrin repeat protein; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein

常规抗体

ANKRD1

Ankyrin repeat domain-containing protein 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

27063

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27063

Q15327

http://www.uniprot.org/uniprotkb/Q15327/entry

107765

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107765

Q9CR42

http://www.uniprot.org/uniprot/Q9CR42

27064

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27064

Q8R560

http://www.uniprot.org/uniprot/Q8R560

The antiserum was produced against synthesized peptide derived from human ANKRD1. AA range:231-280

CARP Polyclonal Antibody detects endogenous levels of CARP protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

36kD

-20°C/1 year

Polyclonal, Rabbit,IgG

ankyrin repeat domain 1(ANKRD1) Homo sapiens The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system. [provided by RefSeq, Jul 2008],

Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.

Nucleus .

disease:Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) [MIM:106700]. TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births.,function:May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.,induction:By TNF, IL1A and parthenolide.,miscellaneous:A chromosomal aberration in the region of ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) [MIM:106700]. Translocation t(10;21)(q23.31;q11.2). The translocation apparently alteres the expression pattern of nearby genes on chromosome 10 by means of a positional effect, and among the genes whose expression pattern is changed due to this chromosomal rearrangement, the ANKRD1 stood out as a plausible candidate gene for TAPVR pathogenesis. This rearrangement apparently does not disrupts any known genes.,similarity:Contains 5 ANK repeats.,subunit:Interacts with YBX1 (By similarity). Interacts with TTN/titin.,tissue specificity:Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.