产品名称
Carbonyl Reductase 1 Rabbit Polyclonal Antibody
别名
CBR1; CBR; CRN; Carbonyl reductase [NADPH] 1; 15-hydroxyprostaglandin dehydrogenase [NADP(+)]; NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase
蛋白名称
Carbonyl reductase [NADPH] 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=873
Human Swissprot No.
P16152
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P16152/entry
Mouse Swissprot No.
P48758
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P48758
免疫原
The antiserum was produced against synthesized peptide derived from human CBR1. AA range:181-230
特异性
Carbonyl Reductase 1 Polyclonal Antibody detects endogenous levels of Carbonyl Reductase 1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013],
组织表达
Expressed in kidney (at protein level).
信号通路
Arachidonic acid metabolism;
功能
catalytic activity:(13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADPH.,catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH.,catalytic activity:R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.,function:Catalyzes the reduction of a wide variety of carbonyl compounds including the antitumor anthracycline antibiotics. Can convert prostaglandin E2 to prostaglandin F2-alpha.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
