产品名称
CaMKIβ Rabbit Polyclonal Antibody
别名
PNCK; Calcium/calmodulin-dependent protein kinase type 1B; CaM kinase I beta; CaM kinase IB; CaM-KI beta; CaMKI-beta; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase
蛋白名称
Calcium/calmodulin-dependent protein kinase type 1B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=139728
Human Swissprot No.
Q6P2M8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6P2M8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93843
Mouse Swissprot No.
Q9QYK9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QYK9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29660
Rat Swissprot Link
http://www.uniprot.org/uniprot/O70150
免疫原
The antiserum was produced against synthesized peptide derived from human CaMK1-beta. AA range:161-210
特异性
CaMKIβ Polyclonal Antibody detects endogenous levels of CaMKIβ protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008],
组织表达
Brain,Liver,Placenta,Thalamus,
细胞定位
Cytoplasm . Nucleus .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by Ca(2+)/calmodulin.,function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1.,PTM:Phosphorylated by CAMKK1.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.