BD-PT0626

CaMKIIβ/γ/δ Rabbit Polyclonal Antibody

CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; CAMK2G; CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase type II subunit gamma;

常规抗体

CAMK2B

Calcium/calmodulin-dependent protein kinase type II subunit beta

WB

Human,Mouse,Rat,Pig

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

816/818/817

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=816

Q13554/Q13555/Q13557

http://www.uniprot.org/uniprotkb/Q13554/entry

12323/12325/108058

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12323

24245/171140/24246

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24245

P08413/P11730/P15791

http://www.uniprot.org/uniprot/P08413

The antiserum was produced against synthesized peptide derived from human CaMK2-beta/gamma/delta. AA range:253-302

CaMKIIβ/γ/δ Polyclonal Antibody detects endogenous levels of CaMKIIβ/γ/δ protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

50+65kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.

ErbB_HER;Calcium;Oocyte meiosis;WNT;WNT-T CELLLong-term potentiation;Neurotrophin;Olfactory transduction;GnRH;Melanogenesis;Glioma;

alternative products:The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ.,tissue specificity:Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.