产品名称
SIM1 Rabbit Polyclonal Antibody
别名
Single-minded homolog 1 (Class E basic helix-loop-helix protein 14) (bHLHe14)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.316% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/6492
Human Swissprot No.
P81133
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P81133/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/20464
Mouse Swissprot No.
Q61045
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q61045
免疫原
Synthesized peptide derived from human SIM1 AA range: 545-595
特异性
This antibody detects endogenous levels of SIM1 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome. [provided by RefSeq, Jul 2008],
功能
function:Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 1 Single-minded C-terminal domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer of SIM1 and ARNT.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
