产品名称
CaMKIIβ/γ Rabbit Polyclonal Antibody
别名
CAMK2G; CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; CaMK-II subunit gamma; CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit bet
蛋白名称
Calcium/calmodulin-dependent protein kinase type II subunit beta/gamma
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=818
Human Swissprot No.
Q13555/Q13554
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13555/entry
Mouse Gene ID
12325/12323
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12325
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171140
Rat Swissprot No.
P11730/P08413
Rat Swissprot Link
http://www.uniprot.org/uniprot/P11730
免疫原
The antiserum was produced against synthesized peptide derived from human CaMK2 beta/gamma. AA range:509-558
特异性
CaMKIIβ/γ Polyclonal Antibody detects endogenous levels of CaMKIIβ/γ protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011],
组织表达
Expressed in skeletal muscle.
细胞定位
Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .
信号通路
ErbB_HER;Calcium;Oocyte meiosis;WNT;WNT-T CELLLong-term potentiation;Neurotrophin;Olfactory transduction;GnRH;Melanogenesis;Glioma;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
