产品名称
Calponin 2 Rabbit Polyclonal Antibody
别名
CNN2; Calponin-2; Calponin H2; smooth muscle; Neutral calponin
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1265
Human Swissprot No.
Q99439
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99439/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12798
Mouse Swissprot No.
Q08093
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q08093
免疫原
The antiserum was produced against synthesized peptide derived from human CNN2. AA range:121-170
特异性
Calponin 2 Polyclonal Antibody detects endogenous levels of Calponin 2 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Several pseudogenes of this gene have been identified, and are present on chromosomes 1, 2, 3, 6, 9, 11, 13, 15, 16, 21 and 22. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015],
组织表达
Heart and smooth muscle.
细胞定位
stress fiber,cytoskeleton,cell-cell junction,cell-cell adherens junction,focal adhesion,membrane,extracellular exosome,
功能
function:Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.,similarity:Belongs to the calponin family.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 3 calponin-like repeats.,tissue specificity:Heart and smooth muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
