产品名称
Calpain 9 Rabbit Polyclonal Antibody
别名
CAPN9; NCL4; Calpain-9; Digestive tract-specific calpain; New calpain 4; nCL-4; Protein CG36
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10753
Human Swissprot No.
O14815
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14815/entry
Mouse Swissprot No.
Q9D805
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D805
免疫原
The antiserum was produced against synthesized peptide derived from human CAPN9. AA range:481-530
特异性
Calpain 9 Polyclonal Antibody detects endogenous levels of Calpain 9 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed predominantly in stomach.
细胞定位
intracellular,cytoplasm,
功能
catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease.,induction:Down-regulated in gastric cancer tissue and in gastric cell lines of differentiated and poorly differentiated types.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 3 EF-hand domains.,tissue specificity:Expressed predominantly in stomach.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
