产品名称
Calpain 11 Rabbit Polyclonal Antibody
别名
CAPN11; Calpain-11; Calcium-activated neutral proteinase 11; CANP 11
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11131
Human Swissprot No.
Q9UMQ6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UMQ6/entry
Mouse Swissprot No.
Q6J756
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6J756
免疫原
The antiserum was produced against synthesized peptide derived from human CAPN11. AA range:401-450
特异性
Calpain 11 Polyclonal Antibody detects endogenous levels of Calpain 11 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008],
组织表达
Highest expression in testis.
细胞定位
Cytoplasmic vesicle, secretory vesicle, acrosome .
功能
catalytic activity:Broad endopeptidase specificity.,function:Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 2 EF-hand domains.,subunit:Heterodimer of a large (catalytic) and a small (regulatory) subunit.,tissue specificity:Highest expression in testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
