产品名称
Cadherin-7 Rabbit Polyclonal Antibody
别名
CDH7; CDH7L1; Cadherin-7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1005
Human Swissprot No.
Q9ULB5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9ULB5/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=241201
Mouse Swissprot No.
Q8BM92
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BM92
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29162
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5DWV2
免疫原
The antiserum was produced against synthesized peptide derived from human CDH7. AA range:651-700
特异性
Cadherin-7 Polyclonal Antibody detects endogenous levels of Cadherin-7 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with bipolar disease in human patients. This gene is present in a gene cluster on chromosome 18. [provided by RefSeq, May 2016],
细胞定位
Cell membrane; Single-pass type I membrane protein.
功能
function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,similarity:Contains 5 cadherin domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
