产品名称
CA XIV Rabbit Polyclonal Antibody
别名
CA14; Carbonic anhydrase 14; Carbonate dehydratase XIV; Carbonic anhydrase XIV; CA-XIV
蛋白名称
Carbonic anhydrase 14
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23632
Human Swissprot No.
Q9ULX7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9ULX7/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23831
Mouse Swissprot No.
Q9WVT6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WVT6
免疫原
The antiserum was produced against synthesized peptide derived from human CA14. AA range:161-210
特异性
CA XIV Polyclonal Antibody detects endogenous levels of CA XIV protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008],
组织表达
High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.
细胞定位
Membrane ; Single-pass type I membrane protein .
信号通路
Nitrogen metabolism;
功能
catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,function:Reversible hydration of carbon dioxide.,similarity:Belongs to the alpha-carbonic anhydrase family.,tissue specificity:High expression in all parts of the central nervous system and lower expression in adult liver, heart, small intestine, colon, kidney, urinary bladder and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
