BD-PT0579

CA VIII Rabbit Polyclonal Antibody

CA8; CALS; Carbonic anhydrase-related protein; CARP; Carbonic anhydrase VIII; CA-VIII

常规抗体

CA8

Carbonic anhydrase-related protein

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

767

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=767

P35219

http://www.uniprot.org/uniprotkb/P35219/entry

12319

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12319

P28651

http://www.uniprot.org/uniprot/P28651

297814

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=297814

Q5PPN4

http://www.uniprot.org/uniprot/Q5PPN4

Synthesized peptide derived from the Internal region of human CA VIII.

CA VIII Polyclonal Antibody detects endogenous levels of CA VIII protein.

IHC-p: 100-300.WB 1:500 - 1:2000. ELISA: 1:40000.. IF 1:50-200

33kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. [provid

cytoplasm,

Nitrogen metabolism;

function:Does not have a carbonic anhydrase catalytic activity.,similarity:Belongs to the alpha-carbonic anhydrase family.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.