产品名称
CA III Rabbit Polyclonal Antibody
别名
CA3; Carbonic anhydrase 3; Carbonate dehydratase III; Carbonic anhydrase III; CA-III
蛋白名称
Carbonic anhydrase 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=761
Human Swissprot No.
P07451
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P07451/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12350
Mouse Swissprot No.
P16015
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P16015
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54232
Rat Swissprot Link
http://www.uniprot.org/uniprot/P14141
免疫原
The antiserum was produced against synthesized peptide derived from human CA3. AA range:141-190
特异性
CA III Polyclonal Antibody detects endogenous levels of CA III protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Carbonic anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes carbonic anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008],
信号通路
Nitrogen metabolism;
功能
catalytic activity:H(2)CO(3) = CO(2) + H(2)O.,cofactor:Zinc.,developmental stage:At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord.,function:Reversible hydration of carbon dioxide.,similarity:Belongs to the alpha-carbonic anhydrase family.,tissue specificity:Muscle specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
