产品名称
C6 Rabbit Polyclonal Antibody
别名
C6; Complement component C6
蛋白名称
Complement component C6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=729
Human Swissprot No.
P13671
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P13671/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24237
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q811M5
免疫原
The antiserum was produced against synthesized peptide derived from human C6. AA range:221-270
特异性
C6 Polyclonal Antibody detects endogenous levels of C6 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012],
信号通路
Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus;
功能
disease:Defects in C6 are the cause of complement component 6 deficiency (C6D) [MIM:612446].,function:Involved in the formation of the lytic c5b-9m complex.,online information:C6 mutation db,polymorphism:The sequence shown is that of allotype C6 B.,PTM:All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 2 Sushi (CCP/SCR) domains.,similarity:Contains 3 TSP type-1 domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
