产品名称
C1QBP Rabbit Polyclonal Antibody
别名
C1QBP; GC1QBP; HABP1; SF2P32; Complement component 1 Q subcomponent-binding protein; mitochondrial; GC1q-R protein; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p33
蛋白名称
Complement component 1 Q subcomponent-binding protein mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=708
Human Swissprot No.
Q07021
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q07021/entry
Mouse Swissprot No.
O35658
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O35658
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29681
Rat Swissprot Link
http://www.uniprot.org/uniprot/O35796
免疫原
The antiserum was produced against synthesized peptide derived from human C1QBP. AA range:61-110
特异性
C1QBP Polyclonal Antibody detects endogenous levels of C1QBP protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008],
组织表达
Expressed on cell surface of peripheral blood cells (at protein level); Surface expression is reported for macrophages and monocyte-derived dendritic cells.
细胞定位
Mitochondrion matrix . Nucleus . Nucleus, nucleolus . Cell membrane ; Peripheral membrane protein ; Extracellular side. Secreted. Cytoplasm . Seems to be predominantly localized to mitochondria. Secreted by activated lymphocytes. Localizes to the nucleolus when coexpressed with POLGARF (PubMed:32958672). Interaction with POLGARF is likely to result in prevention of C1QBP maturation and redirection from mitochondria to nucleoli (PubMed:32958672). .
功能
caution:Was originally (PubMed:1830244 and PubMed:8262387) thought to be a pre-mRNA splicing factor SF2 p32 subunit and to play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing.,function:Not known. Binds to the globular "heads" of C1Q thus inhibiting C1 activation.,similarity:Belongs to the MAM33 family.,subunit:Interacts with Rubella virus capsid protein.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
