产品名称
C/EBP α Rabbit Polyclonal Antibody
别名
CEBPA; CCAAT/enhancer-binding protein alpha; C/EBP alpha
蛋白名称
CCAAT/enhancer-binding protein alpha
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1050
Human Swissprot No.
P49715
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P49715/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12606
Mouse Swissprot No.
P53566
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P53566
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24252
Rat Swissprot Link
http://www.uniprot.org/uniprot/P05554
免疫原
The antiserum was produced against synthesized peptide derived from human C/EBP-alpha. AA range:6-55
特异性
C/EBP α Polyclonal Antibody detects endogenous levels of C/EBP α protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013],
组织表达
Liver,Pancreas,Umbilical cord,White Matter pool- 5 brain tissues- f
细胞定位
Nucleus .; [Isoform 4]: Nucleus, nucleolus .
信号通路
Pathways in cancer;Acute myeloid leukemia;
功能
function:C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP beta and gamma. Interacts with UBN1. Interacts with HBV protein X.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
