产品名称
Bub3 Rabbit Polyclonal Antibody
别名
BUB3; Mitotic checkpoint protein BUB3
蛋白名称
Mitotic checkpoint protein BUB3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9184
Human Swissprot No.
O43684
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43684/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12237
Mouse Swissprot No.
Q9WVA3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WVA3
免疫原
The antiserum was produced against synthesized peptide derived from human BUB3. AA range:279-328
特异性
Bub3 Polyclonal Antibody detects endogenous levels of Bub3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
组织表达
Brain,Epithelium,Placenta,Spleen,Testis,
细胞定位
Nucleus. Chromosome, centromere, kinetochore . Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. .
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能
function:Required for kinetochore localization of BUB1.,similarity:Belongs to the WD repeat BUB3 family.,similarity:Contains 5 WD repeats.,subunit:Interacts with BUB1 and BUBR1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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