产品名称
BST-1 Rabbit Polyclonal Antibody
别名
BST1; ADP-ribosyl cyclase 2; Bone marrow stromal antigen 1; BST-1; Cyclic ADP-ribose hydrolase 2; cADPr hydrolase 2; CD antigen CD157
蛋白名称
ADP-ribosyl cyclase 2
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=683
Human Swissprot No.
Q10588
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q10588/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12182
Mouse Swissprot No.
Q64277
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q64277
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81506
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63072
免疫原
The antiserum was produced against synthesized peptide derived from human BST1. AA range:71-120
特异性
BST-1 Polyclonal Antibody detects endogenous levels of BST-1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane; Lipid-anchor, GPI-anchor.
信号通路
Nicotinate and nicotinamide metabolism;Calcium;
功能
catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,disease:Rheumatoid arthritis (RA) patients show enhanced expression of BST-1 transcripts in bone marrow stromal cell lines. This suggests that BST-1 overexpression may play a role in B-cell abnormalities in RA.,function:Synthesizes cyclic ADP-ribose, a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.,similarity:Belongs to the ADP-ribosyl cyclase family.,subunit:Homodimer.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
