产品名称
BRWD3 Rabbit Polyclonal Antibody
别名
BRWD3; Bromodomain and WD repeat-containing protein 3
蛋白名称
Bromodomain and WD repeat-containing protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=254065
Human Swissprot No.
Q6RI45
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6RI45/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=382236
Mouse Swissprot No.
A2AHJ4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/A2AHJ4
免疫原
The antiserum was produced against synthesized peptide derived from human BRWD3. AA range:1751-1800
特异性
BRWD3 Polyclonal Antibody detects endogenous levels of BRWD3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene contains a bromodomain and several WD repeats. It is thought to have a chromatin-modifying function, and may thus play a role in transcription. Mutations in this gene cause mental retardation X-linked type 93, which is also referred to as mental retardation X-linked with macrocephaly. This gene is also associated with translocations in patients with B-cell chronic lymphocytic leukemia. [provided by RefSeq, May 2010],
组织表达
Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined.
功能
caution:The translocation involving this gene was originally published as t(X;11)(q13;23) (PubMed:15543602), but BRWD3 is localized to Xq21 and not to Xq13.,developmental stage:Expressed in fetal liver.,disease:A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with ARHGAP20 does not result in fusion transcripts but disrupts both genes.,disease:Defects in BRWD3 are the cause of mental retardation X-linked type 93 (MRX93) [MIM:300659]; also known as mental retardation X-linked with macrocephaly. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Mentally retarded individuals are at least twice as likely to have macrocephaly than are their intellectually normal peers.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 2 bromo domains.,similarity:Contains 9 WD repeats.,tissue specificity:Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
