产品名称
Brn-3a Rabbit Polyclonal Antibody
别名
POU4F1; BRN3A; RDC1; POU domain; class 4, transcription factor 1; Brain-specific homeobox/POU domain protein 3A; Brain-3A; Brn-3A; Homeobox/POU domain protein RDC-1; Oct-T1
蛋白名称
POU domain class 4 transcription factor 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5457
Human Swissprot No.
Q01851
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q01851/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18996
Mouse Swissprot No.
P17208
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P17208
Rat Swissprot Link
http://www.uniprot.org/uniprot/P20266
免疫原
The antiserum was produced against synthesized peptide derived from human POU4F1. AA range:311-360
特异性
Brn-3a Polyclonal Antibody detects endogenous levels of Brn-3a protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the POU-IV class of neural transcription factors. This protein is expressed in a subset of retinal ganglion cells and may be involved in the developing sensory nervous system. This protein may also promote the growth of cervical tumors. A translocation of this gene is associated with some adult acute myeloid leukemias. [provided by RefSeq, Mar 2012],
组织表达
Expressed in the brain and the retina. Present in the developing brain, spinal cord and eye.
细胞定位
Nucleus . Cytoplasm .
功能
developmental stage:Expression peaks early in embryogenesis (day 13.5) and is undetectable 14 days after birth.,function:Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons.,similarity:Belongs to the POU transcription factor family. Class-4 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,tissue specificity:Brain. Seems to be specific to the retina. Present in the developing brain, spinal cord and eye.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
