产品名称
Brn-3 Rabbit Polyclonal Antibody
别名
POU4F3; BRN3C; POU domain; class 4, transcription factor 3; Brain-specific homeobox/POU domain protein 3C; Brain-3C; Brn-3C
蛋白名称
POU domain class 4 transcription factor 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5459
Human Swissprot No.
Q15319
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15319/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18998
Mouse Swissprot No.
Q63955
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q63955
免疫原
The antiserum was produced against synthesized peptide derived from human POU4F3. AA range:231-280
特异性
Brn-3 Polyclonal Antibody detects endogenous levels of Brn-3 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009],
组织表达
Brain. Seems to be specific to the retina.
细胞定位
Nucleus . Cytoplasm . Preferentially localized in the nucleus. .
功能
disease:Defects in POU4F3 are the cause of non-syndromic sensorineural deafness autosomal dominant type 15 (DFNA15) [MIM:602459]. DFNA15 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:May play a role in determining or maintaining the identities of a small subset of visual system neurons.,online information:Gene page,similarity:Belongs to the POU transcription factor family. Class-4 subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 POU-specific domain.,tissue specificity:Brain. Seems to be specific to the retina.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
