BD-PT0527

BRMS-1 Rabbit Polyclonal Antibody

BRMS1; Breast cancer metastasis-suppressor 1

常规抗体

BRMS1

Breast cancer metastasis-suppressor 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

25855

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25855

Q9HCU9

http://www.uniprot.org/uniprotkb/Q9HCU9/entry

107392

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107392

Q99N20

http://www.uniprot.org/uniprot/Q99N20

100912000

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100911841

Q5M7T3

http://www.uniprot.org/uniprot/Q5M7T3

The antiserum was produced against synthesized peptide derived from human BRMS1. AA range:21-70

BRMS-1 Polyclonal Antibody detects endogenous levels of BRMS-1 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

28kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.

Nucleus. Cytoplasm. Predominantly nuclear.

function:May be a mediator of metastasis suppression in breast carcinoma.,similarity:Belongs to the BRMS1 family.,tissue specificity:Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.