产品名称
BRCAA1 Rabbit Polyclonal Antibody
别名
ARID4B; BRCAA1; RBBP1L1; RBP1L1; SAP180; AT-rich interactive domain-containing protein 4B; ARID domain-containing protein 4B; 180 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p180; Breast cancer-associated antigen BRCAA1; Hi
蛋白名称
AT-rich interactive domain-containing protein 4B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51742
Human Swissprot No.
Q4LE39
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q4LE39/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94246
Mouse Swissprot No.
A2CG63
Mouse Swissprot Link
http://www.uniprot.org/uniprot/A2CG63
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84481
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9JKB5
免疫原
The antiserum was produced against synthesized peptide derived from human BRCAA1. AA range:761-810
特异性
BRCAA1 Polyclonal Antibody detects endogenous levels of BRCAA1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.
细胞定位
Nucleus . Cytoplasm . Cytoplasmic in breast cancer cells. .
功能
domain:The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.,domain:The C-terminus mediates interaction with mSin3A corepressor complex.,domain:The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.,function:Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.,similarity:Contains 1 ARID domain.,subcellular location:Cytoplasmic in breast cancer cells.,subunit:Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.,tissue specificity:Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
