产品名称
Bradykinin B1 R Rabbit Polyclonal Antibody
别名
BDKRB1; BRADYB1; B1 bradykinin receptor; B1R; BK-1 receptor
蛋白名称
B1 bradykinin receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=623
Human Swissprot No.
P46663
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P46663/entry
Mouse Swissprot No.
Q61125
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61125
免疫原
The antiserum was produced against synthesized peptide derived from human BDKRB1. AA range:201-250
特异性
Bradykinin B1 R Polyclonal Antibody detects endogenous levels of Bradykinin B1 R protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Calcium;Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Regulates Actin and Cytoskeleton;
功能
function:This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.,online information:Bradykinin receptor entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
