产品名称
Bmx Rabbit Polyclonal Antibody
别名
BMX; Cytoplasmic tyrosine-protein kinase BMX; Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38
蛋白名称
Cytoplasmic tyrosine-protein kinase BMX
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=660
Human Swissprot No.
P51813
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P51813/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12169
Mouse Swissprot No.
P97504
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97504
免疫原
The antiserum was produced against synthesized peptide derived from N-ternal human BMX. AA range:11-60
特异性
Bmx Polyclonal Antibody detects endogenous levels of Bmx protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016],
组织表达
Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines.
细胞定位
Cytoplasm . Localizes to the edges of spreading cells when complexed with BCAR1.
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,cofactor:Binds 1 zinc ion per subunit.,domain:SH2 domain mediates interaction with RUFY1.,function:Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.,induction:Activated by IL-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with RUFY1 and RUFY2.,tissue specificity:Preferentially expressed in epithelial and endothelial cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
