BD-PT0505-BMP-8A Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

BMP-8A Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT0505

产品名称

BMP-8A Rabbit Polyclonal Antibody

别名

BMP8A; Bone morphogenetic protein 8A; BMP-8A

类别

常规抗体

基因名称

BMP8A

蛋白名称

Bone morphogenetic protein 8A

推荐应用

反应种属

Human,Rat,Mouse

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

353500

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=353500

Human Swissprot No.

Q7Z5Y6

Human Swissprot Link

http://www.uniprot.org/uniprotkb/Q7Z5Y6/entry

Mouse Swissprot No.

P34821

Mouse Swissprot Link

http://www.uniprot.org/uniprot/P34821

免疫原

The antiserum was produced against synthesized peptide derived from human BMP8A. AA range:253-302

特异性

BMP-8A Polyclonal Antibody detects endogenous levels of BMP-8A protein.

稀释度

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

预测分子量

45-55kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016],

组织表达

Brain,Hippocampus,Thyroid gland,

细胞定位

Secreted .

信号通路

Hedgehog;TGF-beta;

功能

function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 8A entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunofluorescence analysis of A549 cells, using BMP8A Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from COLO cells, using BMP8A Antibody. The lane on the right is blocked with the synthesized peptide.

Western Blot analysis of various cells using BMP-8A Polyclonal Antibody

Western Blot analysis of COLO205 cells using BMP-8A Polyclonal Antibody

Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100（4°,overnight）. High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval. Negetive contrl （right） obtaned from antibody was pre-absorbed by immunogen peptide.