BD-PT0503

BMP-7 Rabbit Polyclonal Antibody

BMP7; OP1; Bone morphogenetic protein 7; BMP-7; Osteogenic protein 1; OP-1; Eptotermin alfa

常规抗体

BMP7

Bone morphogenetic protein 7

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

655

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=655

P18075

http://www.uniprot.org/uniprotkb/P18075/entry

12162

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12162

P23359

http://www.uniprot.org/uniprot/P23359

The antiserum was produced against synthesized peptide derived from human BMP-7. AA range:124-173

BMP-7 Polyclonal Antibody detects endogenous levels of BMP-7 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

55kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016],

Expressed in the kidney and bladder. Lower levels seen in the brain.

Secreted.

Cytokine-cytokine receptor interaction;Hedgehog;TGF-beta;

function:Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.,online information:Bone morphogenetic protein 7 entry,pharmaceutical:Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.,PTM:Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1.,tissue specificity:Expressed in the kidneys and bladder. Lower levels seen in the brain.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.