产品名称
BMP-2 Rabbit Polyclonal Antibody
别名
BMP2; BMP2A; Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A; BMP-2A
蛋白名称
Bone morphogenetic protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=650
Human Swissprot No.
P12643
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P12643/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12156
Mouse Swissprot No.
P21274
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P21274
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29373
Rat Swissprot Link
http://www.uniprot.org/uniprot/P49001
免疫原
The antiserum was produced against synthesized peptide derived from human BMP-2. AA range:226-275
特异性
BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein.
稀释度
IF 1:50-200 WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016],
组织表达
Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
信号通路
Cytokine-cytokine receptor interaction;Hedgehog;TGF-beta;Pathways in cancer;Basal cell carcinoma;
功能
function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1.,tissue specificity:Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
.jpg)
