BD-PT0492

Blk Rabbit Polyclonal Antibody

BLK; Tyrosine-protein kinase Blk; B lymphocyte kinase; p55-Blk

常规抗体

BLK

Tyrosine-protein kinase Blk

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

640

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=640

P51451

http://www.uniprot.org/uniprotkb/P51451/entry

12143

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12143

P16277

http://www.uniprot.org/uniprot/P16277

The antiserum was produced against synthesized peptide derived from human BLK. AA range:456-505

Blk Polyclonal Antibody detects endogenous levels of Blk protein.

WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000. IF 1:50-200

58kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010],

Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.

Cell membrane ; Lipid-anchor . Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). .

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:May function in a signal transduction pathway that is restricted to B-lymphoid cells.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.