BD-PT0483

BCSC-1 Rabbit Polyclonal Antibody

VWA5A; BCSC1; LOH11CR2A; von Willebrand factor A domain-containing protein 5A; Breast cancer suppressor candidate 1; BCSC-1; Loss of heterozygosity 11 chromosomal region 2 gene A protein

常规抗体

VWA5A

von Willebrand factor A domain-containing protein 5A

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

4013

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4013

O00534

http://www.uniprot.org/uniprotkb/O00534/entry

Q99KC8

http://www.uniprot.org/uniprot/Q99KC8

The antiserum was produced against synthesized peptide derived from human LHR2A. AA range:371-420

BCSC-1 Polyclonal Antibody detects endogenous levels of BCSC-1 protein.

WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

86kD

-20°C/1 year

Polyclonal, Rabbit,IgG

VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. Existing as four alternatively spliced isoforms, the gene encoding VWA5A maps to human chromosome 11q24.2.

Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested.

nucleus,nucleoplasm,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.