产品名称
ADA11 Rabbit Polyclonal Antibody
别名
Disintegrin and metalloproteinase domain-containing protein 11 (ADAM 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.327% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/4185
Human Swissprot No.
O75078
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O75078/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/11488
Mouse Swissprot No.
Q9R1V4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9R1V4
免疫原
Synthesized peptide derived from human ADA11 AA range: 600-650
特异性
This antibody detects endogenous levels of ADA11 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],
组织表达
Expressed predominantly in brain. Slightly detected or not at all in other tissues.
细胞定位
Membrane; Single-pass type I membrane protein.
功能
disease:Rearrangements occur in breast and ovarian cancers which involve multiple exons and disrupt the coding region.,domain:A conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor.,function:Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed predominantly in brain. Slightly detected or not at all in other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
