产品名称
Bcl-7a Rabbit Polyclonal Antibody
别名
BCL7A; B-cell CLL/lymphoma 7 protein family member A
蛋白名称
B-cell CLL/lymphoma 7 protein family member A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=605
Human Swissprot No.
Q4VC05
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q4VC05/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=77045
Mouse Swissprot No.
Q9CXE2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CXE2
免疫原
The antiserum was produced against synthesized peptide derived from human BCL7A. AA range:21-70
特异性
Bcl-7a Polyclonal Antibody detects endogenous levels of Bcl-7a protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
功能
disease:Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the BCL7 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
