BD-PT0474

Bcl-6 Rabbit Polyclonal Antibody

BCL6; BCL5; LAZ3; ZBTB27; ZNF51; B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51

常规抗体

BCL6

B-cell lymphoma 6 protein

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

604

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=604

P41182

http://www.uniprot.org/uniprotkb/P41182/entry

12053

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12053

P41183

http://www.uniprot.org/uniprot/P41183

The antiserum was produced against synthesized peptide derived from human Bcl-6. AA range:299-348

Bcl-6 Polyclonal Antibody detects endogenous levels of Bcl-6 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

90kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015],

Expressed in germinal center T- and B-cells and in primary immature dendritic cells.

Nucleus .

B_Cell_Antigen

disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.,disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.,disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.,function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.,induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan.,PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.,tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.