产品名称
BART1 Rabbit Polyclonal Antibody
别名
ARL2BP; BART; BART1; ADP-ribosylation factor-like protein 2-binding protein; ARF-like 2-binding protein; Binder of ARF2 protein 1
蛋白名称
ADP-ribosylation factor-like protein 2-binding protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23568
Human Swissprot No.
Q9Y2Y0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y2Y0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107566
Mouse Swissprot No.
Q9D385
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D385
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=498910
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q4V8C5
免疫原
The antiserum was produced against synthesized peptide derived from human ARL2BP. AA range:101-150
特异性
BART1 Polyclonal Antibody detects endogenous levels of BART1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008],
组织表达
Expressed in retina pigment epithelial cells (at protein level). Widely expressed.
细胞定位
Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. In retina photoreceptor cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet. Interaction with ARL2 may be required for cilia basal body localization. .
功能
function:May play a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ARL2BP family.,subunit:Interacts with GTP bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to ANT1.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
