BD-PT0451

BAP31 Rabbit Polyclonal Antibody

BCAP31; BAP31; DXS1357E; B-cell receptor-associated protein 31; BCR-associated protein 31; Bap31; 6C6-AG tumor-associated antigen; Protein CDM; p28

常规抗体

BCAP31

B-cell receptor-associated protein 31

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

10134

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10134

P51572

http://www.uniprot.org/uniprotkb/P51572/entry

27061

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27061

Q61335

http://www.uniprot.org/uniprot/Q61335

The antiserum was produced against synthesized peptide derived from human BAP31. AA range:151-200

BAP31 Polyclonal Antibody detects endogenous levels of BAP31 protein.

WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

28kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the B-cell receptor associated protein 31 superfamily. The encoded protein is a multi-pass transmembrane protein of the endoplasmic reticulum that is involved in the anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi and in caspase 8-mediated apoptosis. Microdeletions in this gene are associated with contiguous ABCD1/DXS1375E deletion syndrome (CADDS), a neonatal disorder. Alternative splicing of this gene results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 16. [provided by RefSeq, Jan 2012],

Ubiquitous. Highly expressed in neurons and discrete endocrine cells.

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein . May shuttle between the ER and the intermediate compartment/cis-Golgi complex (PubMed:9396746). Associates with the mitochondria-associated endoplasmic reticulum membrane via interaction with TOMM40 (PubMed:31206022). .

disease:Microdeletions in BCAP31 are involved in the contiguous ABCD1/DXS1375E deletion syndrome (CADDS) [MIM:300475]. Patients manifest profound neonatal hypotonia, subsequent failure to thrive, and cholestatic liver disease.,function:May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis.,PTM:Cleaved by CASP8 and other caspases.,similarity:Belongs to the BCAP29/BCAP31 family.,subcellular location:May shuttle between the ER and the intermediate compartment/cis-Golgi complex.,subunit:Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB.,tissue specificity:Ubiquitous.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.