产品名称
AZ1 Rabbit Polyclonal Antibody
别名
OAZ1; OAZ; Ornithine decarboxylase antizyme 1; ODC-Az
蛋白名称
Ornithine decarboxylase antizyme 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4946
Human Swissprot No.
P54368
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P54368/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18245
Mouse Swissprot No.
P54369
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P54369
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25502
Rat Swissprot Link
http://www.uniprot.org/uniprot/P54370
免疫原
The antiserum was produced against synthesized peptide derived from human OAZ1. AA range:14-63
特异性
AZ1 Polyclonal Antibody detects endogenous levels of AZ1 protein.
稀释度
IHC 1:100 - 1:300. ELISA: 1:40000,WB 1:500-2000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms
组织表达
Brain,Fibroblast,Lymphoma,
细胞定位
nucleus,cytoplasm,cytosol,
功能
alternative products:A ribosomal frameshift occurs between the codons for Ser-68 and Asp-69. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines,function:Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.,similarity:Belongs to the ODC antizyme family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
