产品名称
COG7 Rabbit Polyclonal Antibody
别名
Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7)
基因名称
COG7 UNQ3082/PRO10013
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.332% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/91949
Human Swissprot No.
P83436
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P83436/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/233824
Mouse Swissprot No.
Q3UM29
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3UM29
Rat Gene Link
https://www.uniprot.org/uniprot/293456
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q3T1G7
免疫原
Synthesized peptide derived from human COG7 AA range: 245-295
特异性
This antibody detects endogenous levels of COG7 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene resides in the golgi, and constitutes one of the 8 subunits of the conserved oligomeric Golgi (COG) complex, which is required for normal golgi morphology and localization. Mutations in this gene are associated with the congenital disorder of glycosylation type IIe.[provided by RefSeq, May 2010],
组织表达
Brain,Mammary gland,Synovial membrane,
细胞定位
Golgi apparatus membrane ; Peripheral membrane protein .
功能
disease:Defects in COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E) [MIM:608779]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.,function:Required for normal Golgi function.,similarity:Belongs to the COG7 family.,subunit:Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
