产品名称
DAB2 Rabbit Polyclonal Antibody
别名
Disabled homolog 2 (DOC-2) (Differentially-expressed protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.333% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/1601
Human Swissprot No.
P98082
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P98082/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13132
Mouse Swissprot No.
P98078
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P98078
Rat Gene Link
https://www.uniprot.org/uniprot/79128
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O88797
免疫原
Synthesized peptide derived from human DAB2 AA range: 683-733
特异性
This antibody detects endogenous levels of DAB2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
组织表达
Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine. Expressed in kidney proximal tubular epithelial cells (at protein level).
细胞定位
Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, clathrin-coated pit. Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm.
功能
function:Component of the CSF-1 signal transduction pathway.,similarity:Contains 1 PID domain.,subcellular location:Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles.,subunit:Interacts with the globular tail of MYO6. Interacts with DAB2IP. Interacts with NOSTRIN.,tissue specificity:Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
