BD-PT0389

ATF-6β Rabbit Polyclonal Antibody

ATF6B; CREBL1; G13; Cyclic AMP-dependent transcription factor ATF-6 beta; cAMP-dependent transcription factor ATF-6 beta; Activating transcription factor 6 beta; ATF6-beta; Protein G13; cAMP response element-binding protein-related protein;

常规抗体

ATF6B

Cyclic AMP-dependent transcription factor ATF-6 beta

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1388

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1388

Q99941

http://www.uniprot.org/uniprotkb/Q99941/entry

O35451

http://www.uniprot.org/uniprot/O35451

The antiserum was produced against synthesized peptide derived from human ATF6B. AA range:401-450

ATF-6β Polyclonal Antibody detects endogenous levels of ATF-6β protein.

WB 1:500 - 1:2000. ELISA: 1:20000.. IF 1:50-200

90kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],

Ubiquitous.

Endoplasmic reticulum membrane ; Single-pass type II membrane protein .; [Processed cyclic AMP-dependent transcription factor ATF-6 beta]: Nucleus . Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. .

domain:The basic domain functions as a nuclear localization signal.,domain:The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.,function:Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.,PTM:During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.,PTM:N-glycosylated.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC).,tissue specificity:Ubiquitous.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.