产品名称
ATF-3 Rabbit Polyclonal Antibody
别名
ATF3; Cyclic AMP-dependent transcription factor ATF-3; cAMP-dependent transcription factor ATF-3; Activating transcription factor 3
蛋白名称
Cyclic AMP-dependent transcription factor ATF-3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=467
Human Swissprot No.
P18847
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P18847/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11910
Mouse Swissprot No.
Q60765
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q60765
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25389
Rat Swissprot Link
http://www.uniprot.org/uniprot/P29596
免疫原
The antiserum was produced against synthesized peptide derived from human ATF3. AA range:131-180
特异性
ATF-3 Polyclonal Antibody detects endogenous levels of ATF-3 protein.
稀释度
WB 1:500-2000;IHC-p 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
activating transcription factor 3(ATF3) Homo sapiens This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011],
组织表达
Amygdala,Brain,Cerebellum,Muscle,
功能
function:This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a homodimer or a heterodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
