产品名称
Ataxin-2L Rabbit Polyclonal Antibody
别名
ATXN2L; A2D; A2LG; A2LP; A2RP; Ataxin-2-like protein; Ataxin-2 domain protein; Ataxin-2-related protein
蛋白名称
Ataxin-2-like protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11273
Human Swissprot No.
Q8WWM7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8WWM7/entry
Mouse Swissprot No.
Q7TQH0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TQH0
免疫原
The antiserum was produced against synthesized peptide derived from human ATXN2L. AA range:571-620
特异性
Ataxin-2L Polyclonal Antibody detects endogenous levels of Ataxin-2L protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.
细胞定位
Membrane ; Peripheral membrane protein . Cytoplasm . Nucleus speckle . Cytoplasmic granule . Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791). Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791). .
功能
PTM:Arg-361 is dimethylated, probably to asymmetric dimethylarginine.,PTM:Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain.,sequence caution:Exon duplication.,similarity:Belongs to the ataxin-2 family.,subunit:Interacts with MPL/TPOR and EPOR and dissociates after ligand stimulation.,tissue specificity:Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
