产品名称
ASF1B Rabbit Polyclonal Antibody
别名
ASF1B; Histone chaperone ASF1B; Anti-silencing function protein 1 homolog B; hAsf1; hAsf1b; CCG1-interacting factor A-II; CIA-II; hCIA-II
蛋白名称
Histone chaperone ASF1B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55723
Human Swissprot No.
Q9NVP2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NVP2/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66929
Mouse Swissprot No.
Q9DAP7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DAP7
免疫原
The antiserum was produced against synthesized peptide derived from human ASF1B. AA range:101-150
特异性
ASF1B Polyclonal Antibody detects endogenous levels of ASF1B protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in testis and at lower levels in colon, small intestine and thymus.
功能
function:Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis.,PTM:Phosphorylated by TLK1 and TLK2.,similarity:Belongs to the ASF1 family.,subunit:Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with HAT1, NASP, TAF1, TLK1 and TLK2.,tissue specificity:Highly expressed in testis and at lower levels in colon, small intestine and thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
