产品名称
ASCL1 Rabbit Polyclonal Antibody
别名
ASCL1; ASH1; BHLHA46; HASH1; Achaete-scute homolog 1; ASH-1; hASH1; Class A basic helix-loop-helix protein 46; bHLHa46
蛋白名称
Achaete-scute homolog 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=429
Human Swissprot No.
P50553
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P50553/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17172
Mouse Swissprot No.
Q02067
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q02067
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64186
Rat Swissprot Link
http://www.uniprot.org/uniprot/P19359
免疫原
The antiserum was produced against synthesized peptide derived from human ASCL1. AA range:109-158
特异性
ASCL1 Polyclonal Antibody detects endogenous levels of ASCL1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
achaete-scute family bHLH transcription factor 1(ASCL1) Homo sapiens This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008],
组织表达
Lung,Thyroid carcinoma,
功能
function:May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Activates transcription by binding to the E box (5'-CANNTG-3').,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
