产品名称
AR-β3 Rabbit Polyclonal Antibody
别名
ADRB3; ADRB3R; B3AR; Beta-3 adrenergic receptor; Beta-3 adrenoreceptor; Beta-3 adrenoceptor
蛋白名称
Beta-3 adrenergic receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=155
Human Swissprot No.
P13945
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P13945/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11556
Mouse Swissprot No.
P25962
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P25962
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25645
Rat Swissprot Link
http://www.uniprot.org/uniprot/P26255
免疫原
The antiserum was produced against synthesized peptide derived from human ADRB3. AA range:250-299
特异性
AR-β3 Polyclonal Antibody detects endogenous levels of AR-β3 protein.
稀释度
WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009],
组织表达
Expressed mainly in adipose tissues.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Calcium;Neuroactive ligand-receptor interaction;Endocytosis;
功能
function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.,polymorphism:The variant Arg-64 seems to be associated with weight gain (obesity) and to is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed mainly in adipose tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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