产品名称
AR-β1 Rabbit Polyclonal Antibody
别名
ADRB1; ADRB1R; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor
蛋白名称
Beta-1 adrenergic receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=153
Human Swissprot No.
P08588
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P08588/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11554
Mouse Swissprot No.
P34971
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P34971
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24925
Rat Swissprot Link
http://www.uniprot.org/uniprot/P18090
免疫原
The antiserum was produced against synthesized peptide derived from human ADRB1. AA range:281-330
特异性
AR-β1 Polyclonal Antibody detects endogenous levels of AR-β1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane ; Multi-pass membrane protein . Early endosome. Colocalizes with RAPGEF2 at the plasma membrane (By similarity). Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression. .
信号通路
Calcium;Neuroactive ligand-receptor interaction;Endocytosis;Gap junction;Dilated cardiomyopathy;
功能
domain:The PDZ domain-binding motif mediates competitive interactions with GOPC, MAGI3 and DLG4 and plays a role in subcellular location of the receptor.,function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.,PTM:Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subcellular location:Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.,subunit:Interacts with GOPC, MAGI3 and DLG4.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
