产品名称
Arylsulfatase K Rabbit Polyclonal Antibody
别名
ARSK; TSULF; Arylsulfatase K; ASK; Telethon sulfatase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=153642
Human Swissprot No.
Q6UWY0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6UWY0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=77041
Mouse Swissprot No.
Q9D2L1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D2L1
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=365619
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q32KJ2
免疫原
The antiserum was produced against synthesized peptide derived from human ARSK. AA range:481-530
特异性
Arylsulfatase K Polyclonal Antibody detects endogenous levels of Arylsulfatase K protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008],
组织表达
Expressed at high levels in the placenta and pancreas (PubMed:23986440). Expressed at intermediate levels in the lung, brain, heart, liver and kidney and at low levels in the muscle (PubMed:23986440).
细胞定位
Secreted . Lysosome .
功能
cofactor:Binds 1 calcium ion per subunit.,PTM:The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.,similarity:Belongs to the sulfatase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
